The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms

Abstract Thrombotic, vascular, and bleeding complications are the most common causes of morbidity mortality in Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs). In these disorders, circulating red cells, leukocytes, platelets, as well some vascular endothelial each have abnormalities that cell-intrinsic to MPN driver mutations they harbor (eg, JAK2 V617F). When cells activated MPNs, their interactions with other create a highly proadhesive prothrombotic milieu circulation predisposes patients venous, arterial, microvascular thrombosis occlusive disease. Bleeding problems MPNs caused by blood cell-initiated development acquired von Willebrand The inflammatory state created stem microenvironment extends systemically amplify clinical thrombotic tendency and, at same time, preferentially promote further cell clonal expansion, thereby generating vicious cycle favors diseases.